C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/46 (2006.01) A61K 31/40 (2006.01) A61K 47/48 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2528667
The invention relates to compounds that are suitable to be coupled to pharmaceuticals, especially biopharmaceuticals, and to conjugates on the basis of said compounds with biomolecules or pharmaceutically active agents. The inventive compounds can be produced in a simple manner by multicomponent reactions. Another object of the invention is the use of the conjugates as improved formulation of pharmaceuticals and the production thereof. The invention further relates to a laboratory kit for the in vitro production of conjugates on the basis of the inventive compounds and pharmaceuticals and to biotechnological substances, especially biopharmaceuticals, to pharmaceutically active agents, synthetic molecules or surfaces.
La présente invention concerne des composés qui peuvent être combinés à des agents pharmaceutiques, notamment à des agents pharmaceutiques biologiques, ainsi que des conjugués formés de ces composés et de molécules biologiques ou principes actifs pharmaceutiques. Les composés de l'invention peuvent facilement être obtenus par des réactions entre plusieurs composés. L'invention a également pour objet l'utilisation des conjugués en tant que formulation améliorée d'agents pharmaceutiques, et leur préparation. L'invention concerne aussi un kit de laboratoire permettant la préparation in vitro de conjugués à partir des composés de l'invention et d'agents pharmaceutiques, ainsi que des substances de biotechnologie, en particulier des agents pharmaceutiques biologiques, des principes actifs pharmaceutiques, des molécules ou surfaces de synthèse.
Kraehmer Ralf
Leenders Frank
Celares Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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