Sequestering subunit and related compositions and methods

Details Sequestering subunit and related compositions and methods Sequestering subunit and related compositions and methods

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2499550

A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit and a therapeutic agent in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.

L'invention concerne une sous-unité de séquestration comprenant un agent répulsif et un agent bloquant. L'agent bloquant empêche sensiblement la libération de l'agent répulsif de la sous-unité de séquestration dans le tractus gastro-intestinal pendant un laps de temps supérieur à 24 heures. Cette invention concerne également une composition comprenant une sous-unité de séquestration et un agent thérapeutique sous une forme libérable. Eventuellement, la fragilité mécanique de la sous-unité de séquestration est la même que la fragilité mécanique de l'agent thérapeutique sous une forme libérable. L'invention concerne également une capsule ou un comprimé comprenant une sous-unité de séquestration et un agent thérapeutique. Cette invention concerne également un procédé permettant d'empêcher l'abus d'un agent thérapeutique.

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