Recombinant app minigenes for expression in transgenic mice...

C - Chemistry – Metallurgy – 12 – N

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195/1

C12N 15/12 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2040077

ABSTRACT OF THE DISCLOSURE Functional recombinant APP minigene constructs and their introduction into the germline of transgenic mice. Such transgenic mice are useful to generate models of Alzheimer's disease and pathogenesis and are also useful to identify molecular mechanisms of the pathogenesis of Alzheimer's disease.

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