Peptidyl compounds which inhibit metalloproteinase and tnf...

Details Peptidyl compounds which inhibit metalloproteinase and tnf... Peptidyl compounds which inhibit metalloproteinase and tnf...

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217859

Dipeptidyl derivatives having a SH or acylS group and which are amides, thioamides or S(O)0-2-amides, have therapeutic utility via MMP or TNF inhibition.

L'invention porte sur des dérivés dipeptidyle sous forme d'amides, de thioamides ou d'amides S(O)¿0-2?, contenant un groupe SH ou un groupe acyle-S et présentant des possibilités thérapeutiques par inhibition des MMP (métalloprotéinases matricielles) et du TNF (facteur de nécrose tumorale).

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