C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/04 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2599643
The invention concerns compounds of formula I, wherein: R represents H, a halogen, an alkyl, a hydroxy, an alkoxy, a -COOR6, -NR4R5, -NH-SO2-AIk, -NH-CO-AIk, -NR6-CO2-AIk, -0-AIk-COOR6, -0-AIk-NR4R5, -0-(CH2)n-Ph, -CO-NR4R5 or -CO-NH-CH(R7)-(CH2)m-COOR6 radical; R1 represents H, a halogen, a cyano a -COOR6, -NR4R5, -NH-SO2-AIk, -NH-CO-CF3, -NH-CO-Ph, -NH-CO-AIk, -NH-CO2-AIk, -CONR4R5 radical, an optionally substituted phenyl or an optionally substituted heteroaryl; R2 and R3 independently of each other represent a hydroxy, an alkoxy, a -COOR6, a nitro, -NR4R5, -NH-CO-AIk, -NH-CO-Ph, -NH-CO2-Alk, -NH-SO2-alk, -CO-NR4R5 or -CO-NHOH; or R2 and R3 form together, with the carbon atoms of the phenyl ring to which they are bound a 6-membered carbon-containing ring, comprising a nitrogen atom and another heteroatom such as oxygen; in base or salt form, as well as in hydrate or solvate form. The invention also concerns a method for preparing said compounds, pharmaceutical composition containing same and the therapeutic uses thereof.
L'invention concerne des composés de formule I : dans laquelle : R représente H, un halogène, un alkyle, un hydroxy, un alcoxy, un radical -COOR6, -NR4R5, - NH-SO2-AIk, -NH-CO-AIk, -NR6-CO2-AIk, -0-AIk-COOR6, -0-AIk-NR4R5, -0-(CH2)n- Ph, -CO-NR4R5 ou -CO-NH-CH(R7)-(CH2)m-COOR6 ; R1 représente H, un halogène, un cyano, un radical -COOR6, -NR4R5, -NH-SO2-AIk, -NH-CO-CF3, -NH-CO-Ph, -NH-CO- AIk, -NH-CO2-AIk, -CONR4R5, un phényle éventuellement substitué ou un hétéroaryle éventuellement substitué ; R2 et R3 représentent indépendamment l'un de l'autre un hydroxy, un alcoxy, un -COOR6, un nitro, - NR4R5, -NH-CO- AIk, -NH-CO-Ph, -NH-CO2-Alk, -NH-SO2-alk, -CO-NR4R5 ou -CO-NHOH ; ou bien R2 et R3 forment ensemble, avec les atomes de carbone du noyau phényle auquel ils sont rattachés, un cycle carboné à 6 chaînons, comportant un atome d'azote et un autre hétéroatome tel que l'oxygène ; à l'état de base ou de sel, ainsi qu'à l'état d'hydrate ou de solvat. Procédé de préparation, composition pharmaceutique et applications en thérapeutique.
Alcouffe Chantal
Badorc Alain
Bono Francoise
Bordes Marie-Francoise
Robic
Sanofi-Aventis
LandOfFree
Novel imidazo[1,5-a]pyridine derivatives, method for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel imidazo[1,5-a]pyridine derivatives, method for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel imidazo[1,5-a]pyridine derivatives, method for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1463764