Antisense modulation of insulin-like growth factor binding...

Details Antisense modulation of insulin-like growth factor binding... Antisense modulation of insulin-like growth factor binding...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 47/40 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463521

Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor binding protein 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor binding protein 5. Methods of using these compounds for modulation of insulin-like growth factor binding protein 5 expression and for treatment of diseases associated with expression of insulin-like growth factor binding protein 5 are provided.

L'invention concerne des composés antisens, des compositions et des procédés servant à moduler l'expression de la protéine de liaison 5 des facteurs de croissance de type insuline. Lesdites compositions comprennent des composés antisens, en particulier des oligonucléotides antisens, ciblés sur des acides nucléiques codant la protéine de liaison 5 des facteurs de croissance de type insuline. L'invention concerne en outre des procédés d'utilisation desdits composés pour la modulation de l'expression de la protéine de liaison 5 des facteurs de croissance de type insuline et pour le traitement de maladies associées à l'expression de la protéine de liaison 5 des facteurs de croissance de type insuline.

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