Pyridopyrimidine derivatives, their production and use

Details Pyridopyrimidine derivatives, their production and use Pyridopyrimidine derivatives, their production and use

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

D

IPC codes

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 519/00 (2006.01)

Type

Patent

Patent number

CA 2112425

Description

Abstract of the Disclosure The new pyridopyrimidine derivative of the formula (A), wherein n denotes an integer of 0 to 3, Q stands for -(CH2) n - ( m denotes an integer of 0 to 2), -O-, -S(O)p - ( p denotes an integer of 0 to 2 ) or -N-, and R1 to R5 stand for substituents, or its salt is described. Preparation of them and use to endothelin receptor antagonistic agent are exemplified. An endothelin receptor antagonist consisting of said compound is effective as therapeutic composition of acute renal insufficiency, myocardial infraction, hypertension, cerebral infarction, angina pectoris, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction occuring during operation or transplantation of organs. Image (A)

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