Piperidines and piperazines with affinity for 5-ht receptors

Details Piperidines and piperazines with affinity for 5-ht receptors Piperidines and piperazines with affinity for 5-ht receptors

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2133152

Piperidine and piperazine derivatives of the formula I (see formula I) wherein Ind is an indol-3-yl radical which is unsubstituted or mono- or polysubstituted by OH, OA, CN, Hal, COR2 or CH2R2, R1 is benzofuran-5-yl or 2,3-dihydrobenzofuran-5-yl, chroman-6-yl, chroman-4-on-6-yl, 3-chromen-6-yl or chromen-4-on-6-yl, which is unsubstituted or mono- substituted by CN, CH2OH, CH2OA or COR2, Q is C m H 2m, Z is N or CR3, A is alkyl having 1-6 C atoms, Hal is F, C1, Br or I, R2 is OH, OA, NH2, NHA or NA2, R3 is H, OH or OA and m is 2, 3 or 4, and their physiolocally acceptable salts, are active on the central nervous system.

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