Enzymatically inactive phospholipase d of corynebacterium...

Details Enzymatically inactive phospholipase d of corynebacterium... Enzymatically inactive phospholipase d of corynebacterium...

C - Chemistry, Metallurgy

12

N

C12N 9/20 (2006.01) A61K 39/05 (2006.01) A61K 39/08 (2006.01) C07H 21/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/31 (2006.01) C12N 15/55 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2078801

- 15 - ABSTRACT A mutant Corynebacterium pseudotuberculosis phospholipase D product which is enzymatically-inactive and which exhibits the immunogenicity of phospholipase D. A vaccine composition comprising the mutant phospholipase D product is used against caseous lymphadenitis in sheep. Nucleotide and amino acid sequences of the mutant phospholipase D product are disclosed, and a method of production by expression of the mutant gene. A live vaccine composition for in vivo expression of the mutant gene is also disclosed. 920921,jmsspe.001,PLD,15

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