Improved production of rosuvastatin calcium salt

Details Improved production of rosuvastatin calcium salt Improved production of rosuvastatin calcium salt

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01)

Patent

CA 2527314

An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.

L'invention concerne un procédé amélioré de fabrication d'un sel de calcium de (<I>E</I>)-7-[4-(4-fluorophényl)-6-isopropyl-2-[méthyl(méthylsulfonyl)amino]pyrimidine-5-yl](3<I>R</I>,5<I>S</I>)-3,5-dihydroxyhept-6-énoïque (1), que l'on utilise pour la production d'un médicament utile dans le traitement de l'hypercholestérolémie, de l'hyperlipoprotéinémie et de l'athérosclérose, entre autres.

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