C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) G01N 33/52 (2006.01)
Patent
CA 2530591
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
L'invention porte sur de nouveaux procédés et compositions permettant de réguler une réponse immune chez un patient. En particulier, l'invention porte sur des anticorps spécifiques qui régulent l'activité des cellules NK et permettent une potentialisation de la cytotoxicité des cellules NK chez les mammifères. L'invention porte également sur des fragments et des dérivés de tels anticorps, ainsi que sur les compositions pharmaceutiques contenant ces fragments et dérivés, leur utilisation, notamment pour un usage thérapeutique, afin d'augmenter l'activité des cellule NK ou la cytotoxicité chez des patients.
Chiesa Mariella Della
Moretta Alessandro
Innate Pharma
Robic
Universita Di Genova
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