Use of tenascin-w as a biomarker for colon cancer

Details Use of tenascin-w as a biomarker for colon cancer Use of tenascin-w as a biomarker for colon cancer

G - Physics

01

N

G01N 33/574 (2006.01) C07K 14/78 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2702623

The present invention provides a method of detecting, diagnosing or prognosing a colon cancer comprising measuring the concentration of tenascin-W protein in a blood, plasma or serum sample obtained from an individual, and (b) comparing the concentration measured in step (a) with a standard value for the concentration of tenascin-W protein in the blood, plasma or serum of healthy individuals, wherein an increased concentration of tenascin-W as compared to the standard value for the concentration of tenascin-W protein in the blood, plasma or serum of healthy individuals is indicative for the presence of a colon cancer. Kits and antibodies therefore are also provided.

La présente invention propose un procédé pour détecter, diagnostiquer ou pronostiquer un cancer du côlon, qui consiste à mesurer la concentration de la protéine ténascine W dans un échantillon de sang, de plasma ou de sérum obtenu auprès d'un individu, et (b)à comparer la concentration mesurée à l'étape (a) avec une valeur standard pour la concentration de la protéine ténascine W dans le sang, le plasma ou le sérum d'individus sains, une concentration accrue de la ténascine W par comparaison avec la valeur standard pour la concentration de la protéine ténascine W dans le sang, le plasma ou le sérum d'individus sains étant indicative de la présence d'un cancer du côlon. L'invention concerne également des trousses et des anticorps destinés à cet effet.

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