Tetrapeptide regulating blood glucose level in diabetes...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/10 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2547873

The invention refers to the field of medicine and can be applied as a substance capable of regulating glucose level while treating and preventing diabetes mellitus. There is proposed a biologically active new tetrapeptide lysyl-glutamyl-aspartyl-tryptophane of general formula Lys-Glu-Asp-Trp-NH2 capable of regulating the glucose level, and pharmacological substance containing an effective amount of tetrapeptide lysyl-glutamyl-aspartyl- tryptophane of the general formula Lys-Glu-Asp-Trp-NH2. There is proposed the method of prevention and/or treatment of the diabetes mellitus, which consists in administering to a patient of the pharmacological substance, containing as an active peptide agent an effective amount of Lys-Glu-Asp-Trp-NH2 tetrapeptide in doses of 0,1 - 30 ~g/kg of the body weight at least once a day for a period necessary for attaining a therapeutic effect.

La présente invention fait référence au domaine de la médecine et peut s'appliquer en tant que substance capable de réguler le taux de glucose tout en traitant et en évitant le diabète sucré. L'invention concerne un nouveau tétrapeptide lysyl-glutamyl-aspartyl-tryptophane à action biologique de formule générale Lys-Glu-Asp-Trp-NH¿2? capable de réguler le taux de glucose, et une substance pharmaceutiquement acceptable contenant une quantité efficace de tétrapeptide lysyl-glutamyl-aspartyl-tryptophane de formule générale Lys-Glu-Asp-Trp-NH¿2?. L'invention a également pour objet un procédé pour prévenir et/ou traiter le diabète sucré, qui consiste à administrer à un patient une substance pharmacologique contenant comme principe actif peptidique une quantité efficace de tétrapeptide Lys-Glu-Asp-Trp-NH¿2? selon des doses de 0,1 - 30 ?g/kg de masse corporelle, au moins une fois par jour pendant un durée nécessaire pour obtenir l'effet thérapeutique souhaité.

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