A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/19 (2006.01) A61K 31/198 (2006.01) A61K 31/21 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) A61K 38/39 (2006.01) C07C 279/08 (2006.01) C07C 311/06 (2006.01) C07C 311/10 (2006.01) C07D 263/24 (2006.01) C07K 14/78 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2227265
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin .alpha.v.beta.5 antagonists. The .alpha.v.beta.5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor-.alpha. and epidermal growth factor. Inhibition of .alpha.v.beta.5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing .alpha.v.beta.5 antagonists.
Procédés permettant d'inhiber l'angiogenèse dans des tissus en utilisant des antagonistes du récepteur .alpha.¿v?.beta.¿5? de la vitronectine. L'angiogenèse médiée par .alpha.¿v?.beta.¿5? est corrélée à une exposition aux cytokines incluant le facteur de croissance endothélial vasculaire, le facteur de croissance transformant .alpha. et le facteur de croissance épidermique. On cherche surtout à obtenir l'inhibition de l'angiogenèse médiée par .alpha.¿v?.beta.¿5? en cas de maladies néovasculaires oculaires endothéliales, de croissances tumorales et de troubles inflammatoires, à l'aide de compositions thérapeutiques contenant des antagonistes d'.alpha.¿v?.beta.¿5?.
Brooks Peter
Cheresh David A.
Friedlander Martin
Fetherstonhaugh & Co.
The Scripps Research Institute
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