Flow control system

G - Physics – 05 – D

Patent

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Details

G05D 7/06 (2006.01) G01N 30/32 (2006.01) G01N 30/34 (2006.01) G05D 11/13 (2006.01)

Patent

CA 2498034

Method and apparatus for providing liquid flow at a controlled rate less than 100 microliters/minute, and for varying the flow rate in a desired way. A liquid is driven through a conduit by pressure. The rate of flow of the liquid through the conduit is measured and compared to a desired value. The resulting information is then used to make any desirable changes in the driving pressure. In one embodiment, which is particularly suitable for a mixture of liquids to be supplied to a gradient liquid chromatography column, the rate of flow of each of two or more different liquids is controlled individually, and the liquids are then mixed together.

L'invention a trait à un procédé et à un appareil permettant à un liquide de s'écouler à une vitesse contrôlée, inférieure à 100 microlitres/minutes, et permettant de faire varier le débit d'une manière désirée. Un liquide est mis en circulation dans un conduit par pression. Le débit du liquide passant à travers le conduit est mesuré et comparé à une valeur souhaitée. Les informations ainsi obtenues sont ensuite utilisées pour effectuer toute modification souhaitable de la pression motrice. Dans un mode de réalisation, qui est particulièrement adapté à l'apport d'un mélange de liquides à une colonne de chromatographie en phase liquide à gradient, le débit de chacun des deux (ou plus) liquides différents est régulé individuellement, et les liquides sont ensuite mélangés l'un à l'autre.

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