Method for separation of isomers and different conformations...

Details Method for separation of isomers and different conformations... Method for separation of isomers and different conformations...

G - Physics

01

N

G01N 27/62 (2006.01) B01D 59/48 (2006.01) H01J 49/04 (2006.01) H01J 49/42 (2006.01)

Patent

CA 2339553

The present invention relates to a method of separating ions having the same mass to charge ratio but different ion mobility characteristics, based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry. Isomers including gas-phase molecular anions of the amino acids leucine and isoleucine are separable by the method of the present invention. Identification of different conformers of ions at the same charge state, including conformers present at certain charge states of the protein bovine ubiquitin, is also possible using the method of the present invention.

La présente invention concerne un procédé de séparation d'ions ayant le même rapport de masse/charge mais des caractéristiques de mobilité d'ions différentes, basé sur les principes de focalisation d'ions de la spectrométrie de mobilité ionique à forme d'onde asymétrique à haute résolution. Les isomères comprenant des anions moléculaires en phase gazeuse des acides aminés leucines et isoleucines sont séparables par le procédé de la présente invention. Le procédé de la présente invention permet également l'identification de différents conformères d'ions dans le même état de charge, notamment des conformères présents dans certains états de charge de la protéine ubiquitine bovine.

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