Human tumor necrosis factor receptors tr21 and tr22

Details Human tumor necrosis factor receptors tr21 and tr22 Human tumor necrosis factor receptors tr21 and tr22

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2412408

The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to secreening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.

La présente invention concerne deux nouvelles protéines, TR21 et TR22 qui sont des membres du récepteur de facteur de nécrose tumorale (TNF). Cette invention concerne en particulier des molécules d'acide nucléique isolées codantes pour les protéines humaines TR21 et TR22. Cette invention concerne encore les polypeptides TR21 et TR22, des vecteurs, des cellules hôtes et des techniques de recombinaison destinées à produire ces éléments. Cette invention concerne enfin des techniques d'analyse permettant d'identifier des agonistes et des antagonistes de l'activité de TR21 et de TR22, et des techniques de traitement des troubles de l'immunité par l'administration de polynucléotides, de polypeptides, d'agonistes et d'antagonistes TR21 et TR22.

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