C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 60/12 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) B01L 3/00 (2006.01) B01L 9/00 (2006.01)
Patent
CA 2364146
A method for processing a nucleic acid sample contained in a liquid comprises: (a) introducing the liquid into a chamber (11) of a cartridge (12) which contains a chip shaped carrier (14), an active surface (15) of which carries an array of oligonucleotides; (b) positioning cartridge (12) into a cartridge holder (16) which holds cartridge (12); and (c) oscillating cartridge holder (16) and thereby cartridge (12) about an axis of rotation which is perpendicular to a vertical plane, thereby moving cartridge (12) back and forth between a first angular position (26) and a second angular position (28) which lie on opposite sides of an intermediate angular position (27) at which active surface (15) of chip shaped carrier (14) is at the lowest part of its motion path caused by the oscillating motion of cartridge (12). These oscillations cause a relative motion of the sample containing liquid contained in channel (13) with respect to active surface (15) of chip shaped carrier (14). Chamber (11) has a narrow interior and includes a curved channel (13). Chip shaped carrier (14) is located in a central zone of the curved channel (13).
Méthode pour traiter un échantillon d'acide nucléique contenu dans un liquide, comportant les étapes suivantes : a) introduction du liquide dans la chambre (11) d'une cartouche (12) renfermant un support en forme de pastille (14) dont la surface active (15) porte une série d'oligonucléotides; b) positionnement de la cartouche (12) dans un support de cartouche (16) accueillant la cartouche (12); c) balancement du support de cartouche (16) pour faire bouger la cartouche (12) suivant un axe de rotation perpendiculaire à un plan vertical, la cartouche (12) allant et venant ainsi entre une première position angulaire (26) et une seconde position angulaire (28) situées de part et d'autre d'une position angulaire intermédiaire (27) à laquelle la surface active du support en forme de pastille (14) est à la position la plus basse de la trajectoire qui lui est imprimée par le mouvement de balancement de la cartouche (12). Ces oscillations font bouger l'échantillon liquide contenu dans un conduit (13) par rapport à la surface active (15) du support en forme de pastille (14). La chambre (11) possède une cavité étroite ainsi qu'un conduit incurvé (13). Ce support (14) est situé dans la zone centrale du conduit incurvé (13).
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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