C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 17/02 (2006.01) C07K 17/04 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2289742
A method for generating a mixture of activated T-cells by combining a plurality of peripheral blood lymphocytes (PBLs) with an antigen-loaded liposome to produce antigen-loaded PBLs, and combining the antigen-loaded PBLs with a naive, anergic or memory T-cell, to produce an activated T-cell. Such activation is carried out in vivo or in vitro. The antigen-loaded PBLs and activated T-cells, prepared according to the methods of invention, have use as cellular vaccines for treatment of cancer and viral diseases.
Cette invention se rapporte à un procédé de préparation d'un mélange de cellules T activées qui consiste à combiner une pluralité de lymphocytes circulants (PBL peripheral blood lymphocytes) à un liposome chargé d'antigène de façon à produire des PBL chargés d'antigènes, et à combiner ces PBL chargés d'antigènes avec une cellule T naïve, anergique ou à mémoire, de manière à produire une cellule T activée. Une telle activation s'effectue in vivo ou in vitro. Les PBL chargés d'antigènes et les cellules T activées, préparées conformément au procédé de cette invention, s'avèrent utiles en tant que vaccins cellulaires destinés au traitement du cancer et des maladies virales.
Agrawal Babita
Krantz Mark J.
Longenecker B. Michael
Reddish Mark A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biomira Inc.
Oncothyreon Inc.
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