Stat3 inhibitor containing quinolinecarboxamide derivative...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/14 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2729988

The present invention provides a STAT3 inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof. Image 1

L'invention porte sur un inhibiteur de STAT3 qui contient un dérivé de quinoléinecarboxamide représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif. (Dans la formule, W représente une liaison ou une chaîne alkylène ; X représente O, S ou NR34 ; et R1-R8 et R34 représentent chacun H, un atome dhalogène, un groupe alkyle, phényle, furyle, thiényle ou similaire).

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