C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/72 (2006.01) A61K 31/426 (2006.01) A61K 31/435 (2006.01) A61P 9/00 (2006.01) C07D 277/42 (2006.01)
Patent
CA 2672223
The present teachings provide compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
La présente invention concerne des composés de formule (I) et des sels, hydrates et esters pharmaceutiquement acceptables de ceux-ci, où Ar, R1, R2, R3, p et X sont définis ici. La présente invention concerne également des procédés de production desdits composés et de leurs sels, hydrates et esters pharmaceutiquement acceptables, et des procédés de traitement d'une affection ou d'un trouble pathologique, ou de soulagement d'un symptôme de ceux-ci, en utilisant lesdits composés comprenant leurs sels, hydrates et esters pharmaceutiquement acceptables. Les composés peuvent être utiles dans la modulation de l'activité de canal ionique comprenant le traitement d'une variété d'affections associées à la modulation anormale d'un canal calcique dépendant d'un potentiel d'action ou plus.
Baker Christopher Todd
Fensome Andrew
Galullo Vincent P.
Guo Jinsong
Kaplan Justin
Baker Christopher Todd
Fensome Andrew
Galullo Vincent P.
Guo Jinsong
Kaplan Justin
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