Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

Details Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/10 (2006.01) A61K 31/527 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2425283

The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said "A" is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and othter disorders.

La présente invention concerne des inhibiteurs de métalloprotéinase 5-spiro-pyrimidine-2,4,6-trione selon la formule (I), où "A" est un noyau hétérocyclique à 5-7 éléments, tel qu'il est défini dans la spécification, ainsi que des compositions et des procédés pharmaceutiques pour traiter des inflammations, le cancer et d'autres maladies.

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