Pyrido¬2,3-b|indolizine derivatives and aza analogues...

Details Pyrido¬2,3-b|indolizine derivatives and aza analogues... Pyrido¬2,3-b|indolizine derivatives and aza analogues...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 213/57 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 241/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2334671

Disclosed are compounds of formula (I), wherein Ar, R1, R2, R3, W, X, Y, and Z are substituents as defined herein, which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety.

La présente invention concerne les composés de la formule (I), dans laquelle Ar, R¿1?, R¿2?, R¿3?, W, X, Y et Z sont des substituants tels que définis dans cette invention; ces composés sont des agonistes ou des antagonistes partiels hautement sélectifs au niveau des récepteurs CRF¿1? humains, et s'utilisent dans le diagnostic et le traitement des troubles liés au stress tels que la névrose post-traumatique (PTSD), la dépression, les céphalées et l'anxiété.

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