Modulation of cell fates and activities by phthalazinediones

A - Human Necessities – 61 – K

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A61K 31/502 (2006.01)

Patent

CA 2618256

Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.

L'invention concerne des phthalazinediones agissant comme modulateurs rédox et qui s'avèrent utiles dans les traitements de cellules dans plusieurs états de maladie où l'état rédox intracellulaire est affaibli. En amortissant les états rédox aberrants, les phthalazinediones permettent la mise en AEuvre de processus cellulaires fondamentaux pour la survie et accroissent les traitements médicaux. Les phthalazinediones concernés peuvent moduler des fonctions associées à la croissance, à la différenciation, à l'activité ou à la mort de cellules, de façon à corriger les aberrations et à restaurer l'homéostasie et peuvent servir comme thérapie d'appoint dans le traitement de plusieurs maladies.

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