Diazo bicyclic smac mimetics and the uses thereof

Details Diazo bicyclic smac mimetics and the uses thereof Diazo bicyclic smac mimetics and the uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2683318

The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

L'invention concerne des mimétiques diazobicyliques de SMAC qui servent d'inhibiteurs de protéines d'apoptose. L'invention concerne également l'utilisation de ces mimétiques pour induire la mort cellulaire apoptotique et pour sensibiliser les cellules aux inducteurs d'apoptose.

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