Modulation of gm98 (mrf) in remyelination

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2730785

The present invention provides compositions and methods for regulating remyelination and promoting oligodendrocyte differentiation by modulating GM98 (also known as MRF) expression and activity. Compositions and methods for treating neuropathies and screening for bioactive agents are also provided herein.

La présente invention concerne des compositions et des procédés pour réguler la remyélinisation et favoriser la différenciation doligodendrocytes par modulation de lexpression et lactivité de GM98 (également appelé MRF). La présente invention concerne en outre des compositions et des procédés pour traiter des neuropathies et cribler des agents bioactifs.

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