Transfection agents

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 41/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) A61K 47/28 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07J 17/00 (2006.01)

Patent

CA 2528136

The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The compounds, compositions and methods are useful for introducing agents such as genes into individual cells, as well as cells that are present as a tissue or organ.

La présente invention concerne des composés, des compositions et des procédés qui favorisent le transfert d'un agent dans une cellule. Les agents peuvent comprendre des polypeptides, des polynucléotides tels que des gènes et des acides nucléiques antisens, et d'autres molécules. Dans certains modes de réalisation, les agents sont des agents de modulation qui peuvent moduler une activité ou une fonction cellulaire lorsqu'ils sont introduits dans la cellule. Les composés, compositions et procédés sont utilisés pour introduire des agents tels que des gènes dans des cellules individuelles, et dans des cellules présentes sous forme de tissu ou d'organe.

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