Colchicine and thiocolchicine derivatives with...

Details Colchicine and thiocolchicine derivatives with... Colchicine and thiocolchicine derivatives with...

C - Chemistry, Metallurgy

07

C

C07C 323/41 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/335 (2006.01) C07D 303/22 (2006.01) C07D 303/46 (2006.01)

Patent

CA 2234480

The present invention relates to 3-demethyl-thiocolchicine derivatives of general formula (I) (see formula I, II) in which R can be (see formula III) HOCH2-CHOH-CH2-, H2NCH2CHOHCH2-, HOOCCH2-, OH-CH2-CHCl-CH2-, to a process for the preparation thereof, to pharmaceutical compositions containing them and to the use thereof for the preparation of medicaments with muscle relaxant and antiinflammatory activities.

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