Non-metabolizable clomiphene analogs for treatment of...

Details Non-metabolizable clomiphene analogs for treatment of... Non-metabolizable clomiphene analogs for treatment of...

C - Chemistry, Metallurgy

07

C

C07C 323/25 (2006.01) A61K 31/135 (2006.01) C07C 211/48 (2006.01)

Patent

CA 2143000

Compounds of formula (I) wherein R1 and R2 are each selected from the group consisting of C1-C4 lower alkyl; X is NH or S; and n is a whole number within the range of 1-4 inclusive; and when n=0, X is (CH2)3 and the pharmaceutically acceptable salts thereof have been shown to be effective in treating tamoxifen resistant tumors.

Composés représentés par la formule (I) dans laquelle R1 et R2 sont sélectionnés chacun dans le groupe constitué par alkyle inférieur C1-C2; X représente NH ou S; et n est un nombre entier compris entre 1 et 4 inclus; quand n = 0, X représente (CH2)3. Ces composés, ainsi que leurs sels acceptables pharmaceutiquement, se sont avérés efficaces pour traiter des tumeurs résistantes au tamoxifène.

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