Methods of inhibiting musculoaponeurotic fibromatoses...

Details Methods of inhibiting musculoaponeurotic fibromatoses... Methods of inhibiting musculoaponeurotic fibromatoses...

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2244247

A method of inhibiting musculoaponeurotic fibromatoses comprising administering to a mammal in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) ou (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof.

L'invention concerne une méthode pour réduire les fibromatoses musculoaponévrotiques consistant à administrer à un mammifère nécessitant un tel traitement, une quantité suffisante pour être efficace, d'un composé ayant la formule (I). Dans cette formule, R?1¿ et R?3¿ sont, d'une manière indépendante, un hydrogène, -CH¿3?, (a) ou (b), où Ar est un phényle, éventuellement substitué, R?2¿ est choisi dans le groupe constitué par pyrrolidine, hexaméthylèneimino ou pipéridino. L'invention concerne également un sel ou un solvate de ces composés, acceptable sur le plan pharmaceutique.

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