C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/09 (2010.01) C12N 5/078 (2010.01) C12N 5/0789 (2010.01) C07K 16/28 (2006.01)
Patent
CA 2191655
The present invention relates to an antibody composition which contains antibodies specific for glycophorin A, CD3, CD24, CD16, CD14, and optionally CD45RA, CD38, CD36, CD38, CD56, CD2, CD19, CD66e, CD66b, and antibodies specific for antigens expressed on non-hematopoietic tumor cells. A process is provided for enriching and recovering human hematopoietic progenitor cells and stem cells in a sample containing human hematopoietic differentiated, progenitor, and stem cells, and tumor cells. The invention also contemplates tumor-enriching antibody compositions containing antibodies to glycophorin A, CD3, CD19, CD36, CD14, CD16, CD66b, CD66e, CD38, and optionally CD45, CD41, CD33, CD20, CD22, CD29, CD2, CD45RA, and/or CD10 and a process for enriching for metastatic tumor cells in a sample containing the tumor cells and hematopoietic cells. The invention also relates to kits for carrying out these processes and to the cell preparations prepared by the processes.
La présente invention concerne une composition d'anticorps qui contient des anticorps spécifiques pour la glycophorine A, CD3, CD24, CD16, CD14, et éventuellement CD45RA, CD38, CD36, CD38, CD56, CD2, CD19, CD66e, CD66b, et des anticorps spécifiques pour des antigènes exprimés sur des cellules tumorales non hématopoïétiques. On prévoit un procédé permettant d'enrichir et de récupérer des cellules progénitrices hématopoïétiques humaines et des cellules souches dans un échantillon contenant des cellules progénitrices hématopoïétiques humaines et des cellules souches, et des cellules tumorales. L'invention concerne également des compositions d'anticorps à enrichissement tumoral, comprenant des anticorpos pour la glycophorine A, CD3, CD19, CD14, CD36, CD16, CD66b, et éventuellement CD66e, CD38, CD45, CD41, CD33, CD20, CD22, CD29, CD2, CD45RA et/ou CD10 et un procédé d'enrichissement pour des cellules tumorales métastatiques dans un échantillon contenant des cellules tumorales et des cellules hématopoïétiques. L'invention porte en outre sur des trousses pour réaliser ces procédés et sur des préparations cellulaires obtenues par les procédés.
Lansdorp Peter M.
Thomas Terry E.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Stemcell Technologies Inc.
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