C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2573842
The present invention relates to immunoglobulin glycoprotein compositions having predominant N-glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N-glycan structure, wherein said N-glycan structure is Gal2GlcNAc2Man3GlcNAc2 lacking fucose.
Cette invention concerne des compositions de glycoprotéines d'immunoglobulines présentant des structures N- glycane prédominantes sur une glycoprotéine d'immunoglobuline conférant une fonction effectrice spécifique. L'invention concerne également des compositions pharmaceutiques contenant un anticorps présentant une structure N- glycane caractéristique enrichie, ladite structure N glycane étant une glycoforme Gal2GlcNAc2Man3GlcNAc2.exempte de fucose.
Gerngross Tillman U.
Li Huijuan
Wildt Stefan
Glycofi Inc.
Gowling Lafleur Henderson Llp
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