The taga gene and methods for detecting predisposition to...

Details The taga gene and methods for detecting predisposition to... The taga gene and methods for detecting predisposition to...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/106 (2006.01) C07H 21/00 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C12N 1/20 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146862

The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicob- acter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic fragment of the present invention and detecting the reaction of the antigen or fragment and the antibody. A mutant H. pylori not expressing a functional tagA antigen is also provided.

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