Ligands for aggregated tau molecules

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01) C07K 1/13 (2006.01) C07K 14/47 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2737028

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example:formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

La présente invention concerne certains composés de benzothiazole, dimidazothiazole, dimidazopyrimidine et dimidazopyridine, comprenant, par exemple : la formule (I) et leurs sels, hydrates, et solvates pharmaceutiquement et physiologiquement acceptables. De tels composés peuvent être utilisés comme ligands de diagnostic ou marqueurs de la protéine tau et de PHF.

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