Mono and bis alkylamino-anthracyclines

Details Mono and bis alkylamino-anthracyclines Mono and bis alkylamino-anthracyclines

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2112818

An anthracycline glycoside of general formula (1), wherein R1 is hydrogen or methoxy group; R2 is hydrogen or hy- droxy group, A and R both represent hydrogen or one of A and B is hydrogen and the other is hydroxy or a group of formu- la -OSO2R5 in which R5 is C1-C4 alkyl or aryl optionally substituted by C1-C4 alkyl, nitro, amino, methoxy or halogen; R3 is a hydrogen atom or a group of formula (2) and R4 is a group of formula (2): - (CH2)n-X, in which n is 2 or 3 and X is hy- droxy group, a halogen or a group of formula -OSO2R5 in which R5 is as defined above and with the proviso that if R2, X and A are a hydroxy group and R3=H, n must be 3; or a pharmaceutically acceptable salt thereof. Compounds of the in- vention have activity as antitumor agents. Processes for their preparation and pharmaceutical composition containing them are also disclosed.

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