Oestradiol transdermal therapeutic system comprising...

Details Oestradiol transdermal therapeutic system comprising... Oestradiol transdermal therapeutic system comprising...

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2197867

A transdermal therapeutic system comprising the active substance estradiol and having a layered structure of a backing layer which is impermeable to active substances and moisture, an active substance-containing matrix, and, if necessary, a removable protective layer covering the matrix, is characterized by the fact that the matrix comprises glycerol either comprising a maximum of 1%-wt. of water or being substantially free from water.

L'invention concerne un système thérapeutique transdermique contenant de l'oestradiol comme principe actif et comprenant plusieurs couches: une couche dorsale imperméable au principe actif et à l'humidité, une couche de matrice renfermant le principe actif et, le cas échéant, une couche de protection détachable recouvrant la matrice. L'invention se caractérise en ce que la matrice renferme de la glycérine contenant au maximum 1 % en poids d'eau ou pratiquement sans eau.

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