Pyrazine derivatives and pharmaceutical use thereof

Details Pyrazine derivatives and pharmaceutical use thereof Pyrazine derivatives and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4965 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2543644

A pyrazine derivative of the following formula (I): or a salt thereof. The pyrazine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer~s disease, cerebrovascular dementia, dementia accompanying Parkinson~s, disease, etc.), Parkinson~s disease, anxiety, pain, cerebrovascular disease (e.g. stroke), etc.), heart failure and the like.

L'invention concerne un dérivé de pyrazine de formule (I) ou un sel de ce dérivé. Le composé pyrazine (I) et un sel correspondant de la présente invention sont des antagonistes de l'adénosine et sont utiles pour prévenir et/ou traiter la dépression, la démence (par ex., la maladie d'Alzheimer, la démence cérébrovasculaire, la démence accompagnant la maladie de Parkinson, etc.), la maladie de Parkinson, l'anxiété, la douleur, une maladie cérébrovasculaire (par ex., l'accident vasculaire cérébral, etc.), l'insuffisance cardiaque et analogue.

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