Substituted n-aryl amidines as selective d1 dopamine...

C - Chemistry – Metallurgy – 07 – C

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C07C 257/14 (2006.01) C07C 257/18 (2006.01) C07D 295/14 (2006.01)

Patent

CA 2550679

The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

L'invention concerne des composés qui sont de nouveaux antagonistes des récepteurs D¿1?, ainsi que des procédés de préparation de ces composés. La présente invention porte également sur des compositions pharmaceutiques contenant ces antagonistes des récepteurs D¿1? et sur des méthodes d'utilisation de ces composés pour traiter les troubles du système nerveux central, l'obésité, les troubles du métabolisme, les troubles alimentaires tels que l'hyperphagie et le diabète.

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