Neutrokine .alpha.

Details Neutrokine .alpha. Neutrokine .alpha.

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/19 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2665133

The present invention relates to a novel Neutrokine .alpha. protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine .alpha. protein including soluble forms of the extracellular domain. Neutrokine .alpha. polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine .alpha. activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

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