C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 225/04 (2006.01) A61K 31/415 (2006.01) A61P 27/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 498/22 (2006.01)
Patent
CA 2426684
The present invention is directed to spirocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
L'invention concerne des composés spirocycliques qui inhibent la prényl-protéine transférase et la prénylation de la protéine oncogène Ras. L'invention concerne également des compositions chimiothérapeutiques contenant ces composés, ainsi que des procédés pour inhiber la prényl-protéine transférase et la prénylation de la protéine oncogène Ras.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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