C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A01N 37/18 (2006.01) A61K 35/74 (2006.01) A61K 38/14 (2006.01) A61K 39/112 (2006.01) C07K 14/255 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2302866
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as a genetic modification in a biosynthetic pathway gene such as the purI gene. The present invention further relates to the therapeutic use of the mutant $I(Salmonella) for growth inhibition and/or reduction in volume of solid tumors.
La présente invention concerne une espèce de Salmonella mutante présentant un gène msbB modifié génétiquement, la Salmonella mutante étant capable de cibler des tumeurs solides. L'invention concerne également une espèce de Salmonella contenant un gène msbB modifié génétiquement ainsi qu'une modification génétique dans un gène constituant une voie biosynthétique tel que le gène purI. La présente invention concerne également l'utilisation thérapeutique de la Salmonella mutante pour inhiber la croissance et/ou le volume de tumeurs solides.
Bermudes David
Ittensohn Martina
Low Kenneth B.
Osler Hoskin & Harcourt Llp
Vion Pharmaceuticals Inc.
Yale University
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