Formulation of a mixture of free-b-ring flavonoids and...

Details Formulation of a mixture of free-b-ring flavonoids and... Formulation of a mixture of free-b-ring flavonoids and...

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 36/00 (2006.01) A61K 36/48 (2006.01) A61K 36/539 (2006.01)

Patent

CA 2703698

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5- LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

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