4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as...

Details 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as... 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as...

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/505 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2284996

The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)- quinazolines of formula (I), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

La présente invention concerne 4,4-disubstituées-3,4-dihydro-2(1H)-quinazolinones de la formule (I) ou leurs formes stéréoisomères, leurs mélanges stéréoisomères ou encore leurs formes de sels pharmaceutiquement acceptables, ces composés étant utilisés comme inhibiteurs de la transcriptase inverse du VIH. L'invention concerne également des compositions et des kits de diagnostic comprenant ces composés, ainsi que leurs procédés d'utilisation dans le traitement des infections virales. Ces composés peuvent être également utilisés comme solutions étalons ou réactifs pour le dosage.

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