A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2174968
The present invention provides a pharmaceutical composition comprising an estramustine derivative and a cyclodextrin, particularly in the manufacture of a medicament suitable for the oral administration of an estramustine derivative to a patient suffering from a tumor. Estramustine derivatives according to the invention are, for example, compounds of general formula (I) wherein R is (a) or (b) in which R1 is C1-C4 alkyl and n is 0, 1 or 2, and the pharmaceutically acceptable salts thereof.
On décrit une composition pharmaceutique qui comprend un dérivé d'estramustine ainsi qu'une cyclodextrine et qui est destinée notamment à la fabrication d'un médicament conçu pour l'administration orale d'un dérivé d'estramustine à un patient souffrant d'une tumeur. Des dérivés d'estramustine selon l'invention sont, par exemple, des composés de la formule générale (I) ainsi que les sels de ceux-ci, acceptables sur le plan pharmacologique, formule dans laquelle R représente (a) ou (b) où R¿1? représente alkyle C¿1?-C¿4? et n vaut 0, 1 ou 2.
Ab Pharmacia
Buzzi Giovanni
Colombo Giuseppe
Maccari Giuseppe
Martini Alessandro
Ab Pharmacia
Smart & Biggar
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