Kinase inhibitors for preventing or treating pathogen...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/437 (2006.01) A61K 31/395 (2006.01) A61K 31/4985 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2662677

The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.

La présente invention propose des compositions et des procédés d'utilisation de celles-ci pour prévenir et/ou traiter une infection pathogène. La présente invention propose notamment l'utilisation d'inhibiteurs de kinase pour inhiber les kinases qui impliquent des interactions de cellules porteuses d'agent pathogène qui sont associées à des infections pathogènes ou qui les provoquent, pour ainsi prévenir et/ou traiter efficacement les infections pathogènes avec une probabilité bien moins importante d'engendrer une résistance en comparaison avec les antibiotiques et les antiviraux classiques. La présente invention propose également l'utilisation d'inhibiteurs de kinase pour le traitement d'infections pathogènes aiguës pendant une courte période pour éviter des toxicités susceptibles d'être provoquées par une utilisation à long terme de ces inhibiteurs de kinase.

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