Killer t cell activator and use thereof

Details Killer t cell activator and use thereof Killer t cell activator and use thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/70 (2006.01) A61K 39/12 (2006.01) A61K 39/205 (2006.01) A61K 39/245 (2006.01)

Patent

CA 2238661

A protective antigen-specific CTL activator, preferably in the form of a plaster, which comprises the protective antigen and a pharmaceutically acceptable carrier, the activator being used for an external application to an epidermal Langerhans cell surface activated by mechanically or chemically disrupting a stratum corneum of the epidermis, in particular, an activator wherein said plaster comprises a support and an adhesive layer comprising the protective antigen in a releasable manner, said adhesive layer being laminated on one side of the support, a method for activating antigen-specific killer T cell in a mammal using said activator, and use of said protective antigen for the production of a protective antigen-specific T cell activator in a mammal. Inasmuch as the inventive antigen-specific CTL activator amplifies and activates CTL which specifically eradicates only the cells having a protective antigen, it is extremely useful for the prophylaxis and treatment of intractable cancer and diseases caused by viral infection.

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