Modified alpha-lactalbumin

Details Modified alpha-lactalbumin Modified alpha-lactalbumin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A23C 9/20 (2006.01) A23J 1/20 (2006.01) A23J 3/08 (2006.01) A23L 1/305 (2006.01) C07K 14/76 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2167155

Modified .alpha.-lactalbumin, for example of bovine or human origin, comprising fewer phenylalanine residues than wild type .alpha.-lactalbumin may be used as a dietary component for sufferers of hyperphenylalaninemia. Preferably all of the phenylalanine residues are replaced. The modified .alpha.-lactalbumin may be expressed in the mammary gland of non-human host animals so as to accumulate in, and if desired be separated from, their milk.

L' alpha -lactalbumine modifiée, notamment d'origine bovine ou humaine, et comprenant moins de restes de phénylalanine que l' alpha -lactalbumine de phénotype sauvage, peut être utilisée comme constituant alimentaire pour toutes les personnes souffrant d'hyperphénylalaninémie. Tous les restes de phénylalanine sont de préférence remplacés. L' alpha -lactalbumine modifiée, peut être exprimée dans les glandes mammaires d'animaux hôtes afin de s'accumuler dans leur lait, et, le cas échéant, d'être séparée de leur lait.

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