Improved probing of specific nucleic acids

Details Improved probing of specific nucleic acids Improved probing of specific nucleic acids

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2252817

The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a detectable moiety to remain bound if and only if the probe has been cyclized in a target-dependent linking reaction. The invention may be used for distinction between sequence specific vanations of nucleic acids.

L'invention concerne des méthodes améliorées de détection d'acides nucléiques spécifiques, au moyen de sondes circularisables, conçues pour indiquer la présence d'une séquence cible en permettant à une partie détectable de rester liée si, et seulement si, la sonde a été cyclisée dans une réaction de liaison dépendante de la cible. La méthode selon l'invention peut être utilisée pour identifier des variations dans des séquences spécifiques d'acides nucléiques.

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