Human antibodies specific to kdr and uses thereof

Details Human antibodies specific to kdr and uses thereof Human antibodies specific to kdr and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2478169

The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.

L'invention concerne des anticorps qui se lient à <I>KDR</I> avec une affinité comparable ou supérieure à celle du VEGF humain et qui neutralisent l'activation de <I>KDR</I>. Parmi ces anticorps on trouve des immunoglobulines entières, des Fab monovalents et des anticorps simple chaîne, des anticorps simple chaîne multivalents, des dianticorps, des trianticorps et des anticorps simple domaine. L'invention concerne également des acides nucléiques et des cellules hôtes codant pour ces anticorps et exprimant ces anticorps. L'invention concerne également une méthode permettant de neutraliser l'activation de <I>KDR</I>, une méthode permettant d'inhiber l'angiogenèse chez un mammifère ainsi qu'une méthode permettant d'inhiber la croissance tumorale chez un mammifère.

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