Method and compositions for treating emesis, nausea and...

Details Method and compositions for treating emesis, nausea and... Method and compositions for treating emesis, nausea and...

A - Human Necessities

61

K

A61K 31/415 (2006.01)

Patent

CA 2112488

2112488 9300075 PCTABS00019 Methods and compositions are disclosed utilizing the optically pure S(-) isomer of ondansetron. This compound is a potent drug for the treatment of nausea and vomiting associated with chemotherapy and radiation therapy, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron. The S(-) isomer of ondansetron is also useful for the treatment of behavioral disorders such as mood anxiety and schizophrenia, and such other conditions as may be related to S(-) ondansetron's activity as a competitive antagonist of serotonin receptor subtype 5-HT3 such as disorders of gastrointestinal motility, depression, migraine, and as an aid for alcohol withdrawal, nicotine withdrawal, and drug (benzodiazepine et al.) withdrawal, without the concomitant liability of adverse liability of adverse effects associated with the racemic mixture of ondansetron. Furthermore, the S(-) isomer of ondansetron is also useful for the treatment of cognitive disorders such as dementia or age-associated memory impairment, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron.

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